The Importance of Polysaccharides for Brain Health, Immune Function, and Quality of Life
Abstract: This lecture will feature some of the latest nutrition science about the benefits of dietary supplementation and why certain polysaccharides are crucial for health. Dr. Lewis will discuss the results of his extensive line of research on how polysaccharides modulate the immune system and other organ systems in the context of patients with Alzheimer’s, HIV, MS, non-alcoholic fatty liver disease, and healthy adults. Having a proper understanding of the evidence base of dietary supplementation and its relationships to chronic disease is important for all allied health clinicians and wellness industry professionals, especially considering all of the marketing hype around diet, food, and dietary supplements. Dr. Lewis’s lecture provides attendees an evidence-based review of dietary supplement science that emphasizes some recent important findings that have significant impacts on health and quality of life.
Learning objective #1: Attendees will be able to describe the ability of polysaccharides to serve as key nutrients in host defense, repair, and regeneration through their immunomodulatory and antioxidant activities.
Learning objective #2: Attendees will learn how polysaccharides have been shown in clinical trials in Alzheimer’s, HIV, MS, non-alcoholic fatty liver disease, and healthy adults to improve overall quality of life, immune function, and cognition, among other outcomes.
We hope you can join us live on July 20th at 3 PM MT. If not, don’t worry, signing up will still grant you access to the webinar recording.
References that support the lecture:
- Lewis, J. E., Atlas, S., Abbas, M., Rasul, A., Farooqi, A., Lantigua, L., Michaud, F., Goldberg, S., Lages, L., Gao, J., Higuera, O., Fiallo, A., Harvey, P., Tiozzo, E., Woolger, J. M., Ciraula, S., Mendez, A., Rodriguez, A., & Konefal, J. (2020). Cardiovascular, endothelial function, and immune markers in response to treatment with a polysaccharide in HIV+ adults in a randomized, double-blind placebo-controlled trial. Journal of Clinical and Translational Research, 5(3), 140-147.
- Lewis, J. E., Atlas, S., Higuera, O., Fiallo, A., Rasul, A., Farooqi, A., Kromo, O., Lantigua, L., Tiozzo, E., Woolger, J. M., Goldberg, S., Mendez, A., Rodriguez, A., & Konefal, J. (2020). Corrigendum to The effect of a hydrolyzed polysaccharide dietary supplement on biomarkers in adults with non-alcoholic fatty liver disease. Evidence-Based Complementary and Alternative Medicine, 9575878, 1-10. doi: 10.1155/2020/9575878.
- Lewis, J. E., Atlas, S., Abbas, M., Rasul, A., Farooqi, A., Lantigua, L., Lages, L., Michaud, F., Gobbo, L., Higuera, O., Fiallo, A., Tiozzo, E., Woolger, J. M., Ciraula, S., Sneij, R., Goldberg, S., Mendez, A., Rodriguez, A., & Konefal, J. (2019). The novel effects of a hydrolyzed polysaccharide dietary supplement on immune, hepatic, and renal function in adults with HIV in a randomized, double-blind placebo-control trial. Journal of Dietary Supplements. doi: 10.1080/19390211.2019.1619010.
- McDaniel, H.R., LaGanke, C., Bloom, L., Goldberg, S., Hensel, J., Lantigua, L. A., Lages, L. C., Atlas, S. E., Woolger, J.M., & Lewis, J. E. (2019). The effect of broad-spectrum dietary supplementation on quality of life, symptom severity, and functioning in multiple sclerosis. Journal of Dietary Supplements. doi: 10.1080/19390211.2019.1651435.
- Stillman, J., Martin, A., Miguez, M.J., McDaniel, H.R., Konefal, J., Woolger, J.M., & Lewis, J.E. (2019). Relationship between brain-derived neurotrophic factor and immune function during dietary supplement treatment of elderly with Alzheimer’s dementia. Journal of Clinical and Translational Research. 5(2), 68-75.
- McDaniel, H.R., LaGanke, C., Bloom, L., Goldberg, S., Lages, L. C., Lantigua, L. A., Atlas, S. E., Woolger, J.M., & Lewis, J. E. (2018). The effect of a polysaccharide-based multinutrient dietary supplementation regimen on infections and immune functioning in multiple sclerosis. Journal of Dietary Supplements. doi: 10.1080/19390211.2018.1495675.
- Martin, A., Stillman, J., Miguez, M.J., McDaniel, H.R., Konefal, J., Woolger, J.M., & Lewis, J.E. (2017). The effect of dietary supplementation on brain-derived neurotrophic factor and cognitive functioning in Alzheimer’s dementia. Journal of Clinical and Translational Research, 3(3), 1-6.
- Lewis, J. E., McDaniel, H. R., Agronin, M., Loewenstein, D., Riveros, J., Mestre, R., Martinez, M., Colina, N., Abreu, D., Konefal, J., Woolger, J. M., & Ali, K. H. (2013). The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer’s disease. The Journal of Alzheimer’s Disease, 33, 393-406. doi: 10.3233/JAD-2012-121381. PMID: 22976077.
- Ali, K. H., Melillo A., Leonard S., Asthana, D., Woolger, J. M., Wolfson, A. H., McDaniel, H. R., & Lewis, J.E. (2012). An open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adults. Functional Foods in Health and Disease, 2(7), 265-279.
John E. Lewis, Ph.D.
Founder and President of Dr Lewis Nutrition™
John E. Lewis, Ph.D. is past full-time and current Voluntary Associate Professor in the Department of Psychiatry and Behavioral Sciences at the University of Miami Miller School of Medicine and the Founder and President of Dr Lewis Nutrition™ (https://www.drlewisnutrition.com). He is a Diplomate, Faculty Member, and Advisor of the Medical Wellness Association. He has been the principal investigator of over 30 different studies in his research career. During that time, he either directly raised or indirectly supported raising over $23 million in grants, gifts, and contracts for research studies and clinical trials and educational programs for medical students. Much of his research has focused on evaluating the effects of nutrition, dietary supplementation, exercise, and medical devices on various aspects of human health and disease. He and his colleagues have been continually searching for ways to help people achieve and maintain health through natural treatments that align with our physiology.
In addition to his research, Dr. Lewis has been an invited national and international lecturer and guest speaker at conferences and as a guest on television shows, where he discusses not only the findings of his research, but to provide guidance and recommendations as an expert in the field of health and wellness. Furthermore, he has over 180 peer-reviewed publications in scientific journals. His seminal publication from the study in the Journal of Alzheimer’s Disease, not only spurred him to leave academics and pursue a science-based business career, but also enabled him to be selected for a widely-acclaimed TEDxMiami talk (https://www.youtube.com/watch?v=rOJr0sxmxGI) about how dietary supplementation can improve brain health.
Dr. Lewis also embodies the model of health and wellness by eating a whole-food, plant-based diet for over 25 years, taking certain key dietary supplements, and through a rigorous, daily exercise training program. John has a passion for educating others about the value of nutrition, exercise, and health, and he will continue to study the application of clinical nutrition for the benefit of mankind.